![]() ![]() The comparison between the Raman and neutron spectra of free and complexed IBP in the energy range of the Boson peak (BP) gives evidence that the dynamics related to this specific vibrational feature is sensitive to complexation phenomena. The experimental Raman and neutron spectra and the derived Raman coupling function C(R)(ω) show that the complexation process gives rise to a complete amorphization of the drug, as well as to a partial hindering, in the vibrational dynamics of complexes, of the modes between 50 and 150 cm(-1) attributed to CD molecule. Subsequently, the inspection of the same frequency range in the spectra of pure host methyl-β-CD and its IBP-inclusion complexes allows one to identify significant modifications in the vibrational dynamics of the guest molecule after their confinement into CD cavity. The differences observed in the frequency regime 0-100 cm(-1) between the vibrational modes of uncomplexed racemic and enantiomeric IBP are discussed on the basis of comparison with the quantum chemical computation results, taking into account the distinct symmetry properties of the molecules involved in the formation of the host-guest complex. This therapy warrants further controlled trials.The effect of the inclusion into cyclodextrins (CD) cavity on the low-frequency vibrational dynamics of the anti-inflammatory drug ibuprofen (IBP) is here investigated by using Raman and inelastic neutron scattering (INS) experiments. Four to six weeks after IVMP infusion, there was a rapid improvement in muscle enzyme levels, muscle strength, and dysphagia. Although our study has certain limitations, our cohort of adult patients with IIM had marked improvement in clinical and biochemical outcomes. At the end of follow-up, mean strength in the weakest muscle group was 4.7 of 5 (range, 4-5 SD, 0.5), mean peak CK was 480 U/L (range, 37-1016 SD, 337), and the mean prednisone dosage was 15 mg (range, 2.5-60 SD, 21). Four to six weeks after IVMP, dysphagia had resolved in 2 and improved in 3. Four to six weeks after IVMP, the mean strength in the weakest muscle group was 3.3 of 5 (range, 1-5 SD, 1.5) and mean peak CK was 1064 U/L (range, 63-1788, SD, 712). Dysphagia was reported in 5 of the 7 patients at the time of IVMP. ![]() At the time of pulse dose IVMP, the mean strength in the weakest muscle group was rated as 3.1 of 5 (range, 2-4 SD, 0.9) and the mean peak CK was 5746 U/L (range, 1602-14,039 SD, 4911). ![]() Seven patients received pulse dose IVMP for active myositis. Data collected included patient demographics, diagnosis, immunosuppressive therapies, serial serum creatine kinase (CK) measurements, and serial muscle strength testing. Other permanents with the same name will be destroyed even if they have hexproof or protection. We conducted a retrospective chart review of patients who were diagnosed with IIM in the rheumatology clinics of the Cook County Health and Hospital Systems. Here, we systematically analyze the therapeutic effect of pulse dose IVMP in patients with IIM in a large municipal safety net medical center and review the literature on pulse IVMP in adult IIM. Pulse dose intravenous methylprednisolone (IVMP) has been used for serious or refractory cases. Typically high-dose daily oral corticosteroids are used as the first-line therapy of IIM. Idiopathic inflammatory myopathies (IIM) are a rare group of autoimmune diseases characterized by muscle inflammation. ![]()
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